2. Cardiovascular Disease

Cardiovascular Disease

Cardiovascular Disease

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Cardiovascular diseases (CVDs) are the leading causes of death and disability worldwide. CVDs include diseases of the heart, vascular diseases of the brain and diseases of blood vessels. Caused by atherosclerosis, coronary heart disease and cerebrovascular disease are the most common forms of CVDs. Other less common forms of CVDs include rheumatic heart disease and congenital heart disease. A large percentage of CVDs is preventable through the reduction of behavioral risk factors such as tobacco use, physical inactivity and unhealthy diet. Dietary sodium reduction can alleviate the long-term risk of cardiovascular disease events. Statin therapy is an effective intervention in both the primary and secondary preventions of CVDs in those who are at high risk.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-B0131S
    Prostaglandin E1-d4 211105-33-8
    Prostaglandin E1-d4 is the deuterium labeled Prostaglandin E1. Prostaglandin E1 (Alprostadil) is a prostanoid receptor ligand, with Kis of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inhibits platelet aggregation. Prostaglandin E1 can be used as a vasodilator for the research of peripheral vascular diseases[1][2][3].
    Prostaglandin E1-d4
  • HY-B0233S
    Isradipine-d3 1189959-59-8
    Isradipine-d3 (PN 200-110-d3) is the deuterium labeled Isradipine. Isradipine (PN 200-110) is an orally active L-type calcium channel blocker. Isradipine, as a powerful peripheral vasodilator, is a dihydropyridine calcium antagonist with selective actions on the heart as well as the peripheral circulation. Isradipine is a potentially viable neuroprotective agent for Parkinson's disease[1][2][3].
    Isradipine-d3
  • HY-B0683S
    Limaprost-d3 1263190-37-9
    Limaprost-d3 (17α,20-dimethyl-δ2-PGE1-d3) is the deuterium labeled Limaprost. Limaprost (OP1206) is a PGE1 analogue and a potent and orally active vasodilator. Limaprost increases blood flow and inhibits platelet aggregation. Limaprost pain relief, has antianginal effects, and can be used for ischaemic symptoms research[1][2].
    Limaprost-d3
  • HY-B1392S
    Esmolol-d7 hydrochloride 1346598-13-7
    Esmolol-d7 (hydrochloride) is the deuterium labeled Esmolol hydrochloride. Esmolol hydrochloride is a beta adrenergic receptor blocker[1][2].
    Esmolol-d7 hydrochloride
  • HY-B1451S
    Imidapril-d3 hydrochloride 1356017-30-5
    Imidapril-d3 (hydrochloride) (TA-6366-d3) is the deuterium labeled Imidapril hydrochloride. Imidapril hydrochloride (TA-6366) is the hydrochloride salt of Imidapril, an angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity[1][2].
    Imidapril-d3 hydrochloride
  • HY-124208A
    L-770644 dihydrochloride 182251-68-9
    L-770644 is an orally active, potent and selective agonist of the human β3 adrenergic receptor (EC50 = 13 nM).
    L-770644 dihydrochloride
  • HY-B0165CS
    Pravastatin-d3 sodium salt 1329836-90-9 99.02%
    Pravastatin-d3 (sodium) is the deuterium labeled Pravastatin sodium salt. Pravastatin (CS-514) sodium salt is a competitive HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM[1][2].
    Pravastatin-d3 sodium salt
  • HY-B0432AS2
    Propafenone D5 hydrochloride 1346605-05-7
    Propafenone-d5 (hydrochloride) is the deuterium labeled Propafenone hydrochloride. Propafenone (SA-79) hydrochloride is a class of anti-arrhythmic medication, which treats illnesses associated with rapid heart beats such as atrial and ventricular arrhythmias[1].
    Propafenone D5 hydrochloride
  • HY-B0432AS3
    Propafenone-d5 (hydrochloride)(Ethyl) 1398066-02-8
    Propafenone-d5 Ethyl (hydrochloride) is the deuterium labeled Propafenone hydrochloride. Propafenone (SA-79）hydrochloride is a class of anti-arrhythmic medication, which treats illnesses associated with rapid heart beats such as atrial and ventricular arrhythmias[1].
    Propafenone-d5 (hydrochloride)(Ethyl)
  • HY-12502B
    Efonidipine hydrochloride 111011-53-1
    Efonidipine Hcl (NZ-105) is a dual T-type and L-type calcium channel blocker (CCB).
    Efonidipine hydrochloride
  • HY-17421A
    Tenatoprazole sodium 335299-59-7
    Tenatoprazole sodium (TU-199 sodium) is a proton pump inhibitor; inhibits hog gastric H+/K+-ATPase with an IC50 of 6.2 μM.
    Tenatoprazole sodium
  • HY-P0266
    N-Acetyl-Ser-Asp-Lys-Pro 127103-11-1
    N-Acetyl-Ser-Asp-Lys-Pro, an endogenous tetrapeptide secreted by bone marrow, is a specific substrate for the N-terminal site of ACE.
    N-Acetyl-Ser-Asp-Lys-Pro
  • HY-P0316
    TP508 121341-81-9
    TP508 is a 23-amino acid nonproteolytic thrombin peptide that represents a portion of the receptor-binding domain of thrombin molecule. TP508 activates endothelial NO synthase (eNOS) and stimulates production of NO in human endothelial cells. TP508 activates endothelial cells and stem cells to revascularize and regenerate tissues.
    TP508
  • HY-101628
    VEGFR-2-IN-9 408502-06-7
    VEGFR-2-IN-9 (KDR-in-4) is a potent kinase insert domain-containing receptor (KDR/VEGFR2) inhibitor with an IC50 of 7 nM.
    VEGFR-2-IN-9
  • HY-101682
    SCH 42495 136511-43-8
    SCH 42495 is an orally active neutral metalloendopeptidase (NEP) inhibitor with antihypertensive effect. SCH 42495 is the orally active ethylester proagent of SCH 42354.
    SCH 42495
  • HY-101759
    Isoxsuprine-monoester-1 67160-74-1
    Isoxsuprine-monoester-1, a monoester of isoxsuprine, is a long acting peripheral vasodilator.
    Isoxsuprine-monoester-1
  • HY-U00354
    CP-060 180090-15-7
    CP-​060 is a potent Ca2+ antagonist, inhibits Ca2+ overload and possesses antioxidant and cardioprotective activities.
    CP-060
  • HY-101644
    Saterinone 102669-89-6
    Saterinone is a phosphodiesterase III (PDE III) inhibitor.
    Saterinone
  • HY-101690
    QF0301B 149247-12-1
    QF0301B is an α1 adrenergic receptor antagonist and a low α2 adrenoceptor, 5-HT2A, and histamine H1 receptor blocker.
    QF0301B
  • HY-101729
    Anti-Heart Failure Agent 1 142648-47-3
    Anti-Heart Failure Agent 1 an orally available compound suitable for the treatment of heart failure without inducing nausea, vomiting and restlessness.
    Anti-Heart Failure Agent 1
Cat. No. Product Name / Synonyms Application Reactivity